There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. 27 Mayo Clinic College of Medicine, Rochester, MN, USA.25 Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC, USA.24 Dept of Respiratory Medicine, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand.23 Bronchiectasis Group, IDIBGI, CIBERES, Dr Trueta University Hospital, Girona, Spain.22 Dept of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.21 Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany.20 Behavioral Health Systems Research, Miami, FL, USA.19 Fundaciò Clìnic, IDIBAPS, CIBERES, Hospital Clinic de Barcelona, Barcelona, Spain.18 Service de Pneumologie, Hopital Larrey, CHU de Toulouse, Toulouse, France.17 Concord Hospital, Concord, Australia.16 Pneumology Service, Universitary and Polytechnic Hospital La Fe, Valencia, Spain.15 Host Defence Unit, Royal Brompton Hospital, London, UK.14 Dept of Respiratory Disease, UZ Leuven, Leuven, Belgium.13 Dept of Respiratory Medicine, AZ Nikolaas, Sint-Niklaas, Belgium.12 Dept of Medicine and Pediatrics, Medical University of South Carolina, Charleston, SC, USA.11 Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.10 Imperial College and Royal Brompton Hospital, London, UK.9 5th Pulmonary Dept, 'Sotiria' Chest Hospital, Athens, Greece.

8 Institute of Cellular Medicine, Newcastle University and Bronchiectasis Service Freeman Hospital, Newcastle upon Tyne, UK.7 College of Medicine University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.6 Dept of Pulmonary Diseases, Medical Centre Alkmaar, Alkmaar, The Netherlands.5 Dept of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA.4 Respiratory Unit, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dept of Pathophysiology and Transplantation, University of Milan, Milan, Italy.3 Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.1 Royal Infirmary and University of Edinburgh, Edinburgh, UK 2 Joint first authors.

Flume definition